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Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration

   
@article{APS9924,
	author = {Meng Liu and Jie Yuan and Wen-juan Hu and Chang-qiang Ke and Yi-fan Zhang and Yang Ye and Da-fang Zhong and Guang-rong Zhao and Sheng Yao and Jia Liu},
	title = {Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration},
	journal = {Acta Pharmacologica Sinica},
	volume = {40},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {The influence of broad-spectrum antibiotics on the pharmacokinetics and biotransformation of major constituents of Shaoyao-Gancao decoction (SGD) in rats was investigated. The pharmacokinetic behaviors of paeoniflorin (PF), albiflorin (AF), liquiritin (LT), isoliquiritin (ILT), liquiritin apioside (LA), isoliquiritin apioside (ILA), and glycyrrhizic acid (GL), seven major constituents of SGD, as well as glycyrrhetinic acid (GA), a major metabolite of GL, were analyzed. A 1-week pretreatment with broad-spectrum antibiotics (ampicillin, metronidazole, neomycin, 1 g L−1; and vancomycin, 0.5 g L−1) via drinking water reduced plasma exposure of the major constituents. The AUC0-24 h of PF and LT was significantly decreased by 28.7% and 33.8% (P },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9924}
}