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MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells

   
@article{APS9889,
	author = {Xian-bo Huang and Chun-mei Yang and Qing-mei Han and Xiu-jin Ye and Wen Lei and Wen-bin Qian},
	title = {MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {39},
	number = {12},
	year = {2018},
	keywords = {},
	abstract = {Although the treatment of adult T-cell acute lymphoblastic leukemia (T-ALL) has been significantly improved, the heterogeneous genetic landscape of the disease often causes relapse. Aberrant activation of mammalian target of rapamycin (mTOR) pathway in T-ALL is responsible for treatment failure and relapse, suggesting that mTOR inhibition may represents a new therapeutic strategy. In this study, we investigated whether the mTOR complex 1 (mTORC1) inhibitor everolimus could be used as a therapeutic agent against human T-ALL. We showed that rapamycin and its analog RAD001 (everolimus) exerted only mild inhibition on the viability of Jurkat, CEM and Molt-4 cell lines (for everolimus the maximum inhibition was },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9889}
}