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Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome

   
@article{APS9739,
	author = {Meng-yao AN and Kai SUN and Yan LI and Ying-ying PAN and Yong-qiang YIN and Yi KANG and Tao SUN and Hong WU and Wei-zhen GAO and Jian-shi LOU},
	title = {Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome},
	journal = {Acta Pharmacologica Sinica},
	volume = {39},
	number = {3},
	year = {2018},
	keywords = {},
	abstract = {Abstract
Short QT syndrome (SQTS) is a genetic arrhythmogenic disease that can cause malignant arrhythmia and sudden cardiac death. The current therapies for SQTS have application restrictions. We previously found that Mg· (NH2CH2CH2SO3)2· H2O, a taurine-magnesium coordination compound (TMCC) exerted anti-arrhythmic effects with low toxicity. In this study we established 3 different models to assess the potential anti-arrhythmic effects of TMCC on type 2 short QT syndrome (SQT2). In Langendorff guinea pig-perfused hearts, perfusion of pinacidil (20 μmol/L) significantly shortened the QT interval and QTpeak and increased rTp-Te (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9739}
}