@article{APS9514,
author = {Qing LI and Ting-ting TANG and Feng JIANG and Rong ZHANG and Miao CHEN and Jun YIN and Yu-qian BAO and Xiang CHENG and Cheng HU and Wei-ping JIA},
title = {Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes},
journal = {Acta Pharmacologica Sinica},
volume = {38},
number = {1},
year = {2017},
keywords = {},
abstract = {KCNQ1 channel is a member of the voltage-gated potassium channel KQT-like subfamily. The KCNQ1 gene has recently been identified as a susceptibility locus for type 2 diabetes mellitus (T2DM). In the present study, we examined the effects of KCNQ1 variants on the therapeutic response to modified-release gliclazide (gliclazide MR) treatment in Chinese patients newly diagnosed with T2DM. A total of 100 newly diagnosed T2DM patients without a history of any anti-diabetic medications were treated with gliclazide MR for 16 weeks, but 91 patients completed the entire study. The anthropometric parameters were determined at baseline and at the final visit, while clinical laboratory tests were performed at baseline and on weeks 2, 4, 6, 12, 16. Two SNPs, rs2237892 and rs2237895, in the region of the KCNQ1 gene were genotyped in all the participants. All calculations and statistical analyses were conducted using SPSS. The rs2237892 TT homozygotes exhibited significantly higher 2-h glucose levels at baseline (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9514}
}