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High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139

   
@article{APS9360,
	author = {Jia Wang and Lin-yun Zhu and Qing Liu and Morten Hentzer and Garrick Paul Smith and Ming-wei Wang},
	title = {High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139},
	journal = {Acta Pharmacologica Sinica},
	volume = {36},
	number = {7},
	year = {2017},
	keywords = {},
	abstract = {Aim: To discover antagonists of the orphan G-protein coupled receptor GPR139 through high-throughput screening of a collection of diverse small molecules.
Methods: Calcium mobilization assays were used to identify initial hits and for subsequent confirmation studies.
Results:  Five small molecule antagonists, representing 4 different scaffolds, were identified following high-throughput screening of 16 000 synthetic compounds.
Conclusion: The findings provide important tools for further study of this orphan G-protein coupled receptor.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9360}
}