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Histone lysine methyltransferases as anti-cancer targets for drug discovery

   
@article{APS9253,
	author = {Qing LIU and Ming-wei WANG},
	title = {Histone lysine methyltransferases as anti-cancer targets for drug discovery},
	journal = {Acta Pharmacologica Sinica},
	volume = {37},
	number = {10},
	year = {2017},
	keywords = {},
	abstract = {Post-translational epigenetic modification of histones is controlled by a number of histone-modifying enzymes. Such modification regulates the accessibility of DNA and the subsequent expression or silencing of a gene. Human histone methyltransferases (HMTs)constitute a large family that includes histone lysine methyltransferases (HKMTs) and histone/protein arginine methyltransferases (PRMTs). There is increasing evidence showing a correlation between HKMTs and cancer pathogenesis. Here, we present an overview of representative HKMTs, including their biological and biochemical properties as well as the profiles of small molecule inhibitors for a comprehensive understanding of HKMTs in drug discovery.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9253}
}