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The role of the orphan nuclear receptor COUP-TFII in tumorigenesis

  
@article{APS9216,
	author = {Mafei Xu and Jun Qin and Sophia Y Tsai and Ming-jer Tsai},
	title = {The role of the orphan nuclear receptor COUP-TFII in tumorigenesis},
	journal = {Acta Pharmacologica Sinica},
	volume = {36},
	number = {1},
	year = {2017},
	keywords = {},
	abstract = {The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9216}
}