@article{APS9215,
author = {Kazuhiro Ikeda and Kuniko Horie-Inoue and Satoshi Inoue},
title = {Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology},
journal = {Acta Pharmacologica Sinica},
volume = {36},
number = {1},
year = {2017},
keywords = {},
abstract = {Estrogens are important endocrine hormones that control physiological functions in reproductive organs, and play a pivotal role in the generation and progression of breast cancer. Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer. The estrogen receptors, ERα and ERβ, function as hormone-dependent transcription factors that directly regulate the expression of their target genes. Therefore, a better understanding of the function and regulation of estrogen-responsive genes provides insight into the gene regulation network associated with breast cancer. Recent technological developments in high-throughput sequencing have enabled the genome-wide identification of estrogen-responsive genes. Further elucidating the estrogen gene cascade is critical for advancements in the diagnosis and treatment of breast cancer.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9215}
}