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Muscarinic receptor activities potentiated by desensitization of nicotinic receptors in rat superior cervical ganglia

  
@article{APS9170,
	author = {Qin Wan and Zhi-Pu Luo and Hai Wang},
	title = {Muscarinic receptor activities potentiated by desensitization of nicotinic receptors in rat superior cervical ganglia},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {7},
	year = {2016},
	keywords = {},
	abstract = {AIM: The influences of desensitized nicotinic acetylcholine receptors (nAChR) on the activities of muscarinic acetylcholine receptors (mAChR) were investigated in single cultured rat superior cervical ganglion. 
METHODS: Whole-cell patch-clamp techniques were used. 
RESULTS: An inward current was induced by nicotine 80 micromol/L in the sympathetic neurons and desensitized rapidly after the prolonged exposure to nicotine. An outward current was induced by oxotremorine 100 micromol/L or pilocarpine 100 micromol/L and it showed no desensitization after exposure to its agonists. After nAChR desensitized completely, the current evoked by oxotremorine was increased significantly compared with its control. There were (42 38) % (n=8, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9170}
}