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Endothelin-1 promoted proliferation of vascular smooth muscle cell through pathway of extracellular signal-regulated kinase and cyclin D1.

   
@article{APS9158,
	author = {Ying-Min Zhang and Ke-Qiang Wang and Guo-Min Zhou and Ji Zuo and Jun-Bo Ge},
	title = {Endothelin-1 promoted proliferation of vascular smooth muscle cell through pathway of extracellular signal-regulated kinase and cyclin D1.},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM: To investigate whether endothelin-1 (ET-1) can promote human umbilical artery smooth muscle cell (HUASMC) proliferation through pathway of extracellular signal-regulated kinase (ERK) and cyclin D1. METHODS: The effects of ET-1 and PD98059 on HUASMC were evaluated by MTT assay. The content of DNA was defined by [3H]TdR assay and cell cycle was analyzed by flow cytomerty. Western blot analysis was employed to detect the active phosphorylated state of ERK and the expression of cylin D1. RESULTS: Firstly, ET-1 (100 nmol/L) stimulated HUASMC proliferation compared with the group without ET-1 (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9158}
}