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Isoprenaline and aminophylline relax bronchial smooth muscle by cAMP-induced stimulation of large-conductance Ca2+-activated K+ channels.

   
@article{APS9106,
	author = {Xian-Sheng Liu and Yong-Jian Xu and Zhen-Xiang Zhang and Chao-Qian Li and Dan-Lei Yang and Ning Zhang and Wang Ni},
	title = {Isoprenaline and aminophylline relax bronchial smooth muscle by cAMP-induced stimulation of large-conductance Ca2+-activated K+ channels.},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To investigate whether the relaxation of bronchial smooth muscle induced by isoprenaline and aminophylline is mediated by large conductance Ca2+-activated K+ channels (BK(Ca)) via cAMP-dependent mechanism. METHODS: With isometric tension recording, the role of BK(Ca) in relaxations of rat bronchial strips induced by isoprenaline and aminophylline was determined. With perforated patch-clamp technique, BK(Ca) currents were observed in freshly isolated rat bronchial myocytes. RESULTS: Tetraethylammonium 5 mmol/L, a BK(Ca) blocker, caused a significant rightward shift in the concentration-response curves of isoprenaline and aminophylline (about 4.26-fold and 3.78-fold, respectively) in methacholine-precontracted rat bronchial strips. Isoprenaline 1 micromol/L caused a significant increase in BK(Ca) current from (94+/-15) pA/pF to (186+/-30) pA/pF (voltage steps from -60 mV to +50 mV, n=10, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9106}
}