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Different synaptic mechanisms of long-term potentiation induced by nicotine and tetanic stimulation in hippocampal CA1 region of rats.

  
@article{APS9104,
	author = {Jin He and Chun-Yu Deng and Xiao-Nan Zhu and Jian-Ping Yu and Ru-Zhu Chen},
	title = {Different synaptic mechanisms of long-term potentiation induced by nicotine and tetanic stimulation in hippocampal CA1 region of rats.},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To investigate whether long-term potentiation (LTP) induced by nicotine and tetanic stimulation in the hippocampal CA1 region shares different mechanisms. METHODS: Extracellular population spikes of the pyramidal cell layer in the hippocampal CA1 region were recorded in vitro. RESULTS: LTP induced by the tetanic stimulation could be facilitated by nicotine 10 micromol/L, meanwhile, the tetanic stimulation did the same effect on LTP induced by nicotine 10 micromol/L. MK-801 10 micromol/L or NG-nitro-L-arginine methyl ester (L-NAME) 20 micromol/L blocked LTP induced by tetanic stimulation, but did not inhibit LTP induced by nicotine. CONCLUSION: LTP induced by nicotine shares different synaptic mechanisms with LTP induced by tetanic stimulation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9104}
}