@article{APS9082,
author = {Xiu-Fen Yang and Nai-Ping Wang and Wen-Hong Lu and Fan-Dian Zeng},
title = {Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the effects of Ginkgo biloba extract (GbE) and tanshinone (Tan) on cytochrome P450 (CYP) isozymes and glutathione transferase (GT) in rats.
METHODS: Several CYP-dependent reactions were monitored in liver and kidney microsomes of male rats treated ig with GbE and Tan daily for 10 d. The activity of GT, the levels of malondialdehyde (MDA) and nitric oxide (NO) in the tissues were also determined.
RESULTS: CYP1A1, 1A2, and 2B1 activities in the liver were all significantly increased (2-9.5 fold) by pretreatment with GbE or Tan (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9082}
}