@article{APS9063,
author = {Shao-Jun Shi and Hui Chen and Shi-Fen Gu and Fan-Dian Zeng},
title = {Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM: To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs.
METHODS: The plasma drug concentration was determined by the reversed-phase HPLC method and the effects on cardiac and hemodynamics were recorded by polygraph. The pharmacokinetic and PK-PD model parameters were calculated.
RESULTS: The pharmacokinetics were best fitted to a two-compartment open model, and the relationship between effect and effect compartment concentration of both drugs could be represented by the sigmoid-E(max) model. There were no significant differences in main pharmacokinetics and PK-PD parameters between the two drugs.
CONCLUSION: No statistically different kinetic disposition characteristics and potencies of inhibitory effects on myocardial function of daurisoline and dauricine were found in beagle dogs.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9063}
}