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Expression of core binding factor alpha1 up-regulated by IGF-I, GM-CSF, and EGF through MAPK pathway in MC3T3-E1 and C2C12 cells

   
@article{APS9053,
	author = {Yu Pei and Xun-Wu Meng and Xue-Ying Zhou and Xiao-Ping Xing and Wei-Bo Xia},
	title = {Expression of core binding factor alpha1 up-regulated by IGF-I, GM-CSF, and EGF through MAPK pathway in MC3T3-E1 and C2C12 cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {10},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the regulating function and mechanism of insulin-like growth factor-I (IGF-I), granulocyte-macrophage colony-stimulating factor (GM-CSF), and epidermal growth factor (EGF) on murine core binding factor alpha1 (Cbfalpha1) gene expression. 
METHODS: Luciferase reporter gene method and RT-PCR technique were used to examine the effects of these growth factors on the promoter activity and mRNA expression of Cbfalpha1 gene in MC3T3-E1 and C2C12 cells. 
RESULTS: IGF-I (from 1 nmol/L to 1 micromol/L), GM-CSF (100 nmol/L), and EGF (1 micromol/L) increased the luciferase expression in MC3T3-E1 cells (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9053}
}