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Effect of ghrelin on septic shock in rats.

  
@article{APS9019,
	author = {Lin Chang and Jun-Bao Du and Lian-Ru Gao and Yong-Zheng Pang and Chao-Shu Tang},
	title = {Effect of ghrelin on septic shock in rats.},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the role of ghrelin in the late stage of septic shock in rats. METHODS: The rat model of septic shock was made by caecal ligation and perforation. At the time of operation ghrelin 10 nmol/kg was infused through femoral vein followed by a sc injection at 8 h after operation. Hemodynamic parameters including heart rate (HR), mean arterial blood pressure (MABP), LVdp/dtmax, and left ventricular end-diastolic pressure (LVEDP) in survival rats were measured at 18 h after surgery. Plasma glucose and lactate concentrations, plasma ghrelin level and myocardial ATP content were assayed. The mortality rate in rats with septic shock was also observed. RESULTS: Compared to that of septic shock group, MABP of rats in ghrelin-treated group increased by 33 % (P },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9019}
}