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Quercetin down-regulated bcl-2 gene expression in human leukemia HL-60 cells

  
@article{APS9001,
	author = {Dong Xiao and Zhen-Lun Gu and Shou-Peng Zhu},
	title = {Quercetin down-regulated bcl-2 gene expression in human leukemia HL-60 cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of quercetin (Que) on bcl-2 gene expression in human leukemia HL-60 cells. 
METHODS: Immunohistochemical analysis and RNA Dot blot hybridization were used to identify the expression of bcl-2 genes. 
RESULTS: The expression of bcl-2 protein was 94% in control HL-60 cells, which became 45%-84% when they were cultured with Que 15-60 mumol.L-1 for 48 h. The expression of bcl-2 mRNA in HL-60 cells was obviously decreased in treatment with Que 15-60 mumol.L-1. CONCLUSION: The apoptotic action of Que in HL-60 cells was associated with the down-regulation of the apoptosis-suppressing gene bcl-2.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9001}
}