@article{APS8998,
author = {Kazuyoshi Kurahashi and Tsuyoshi Nishihashi and Cristina Corina Trandafir and Ai-Min Wang and Shizuka Murakami and Xu Ji},
title = {Diversity of endothelium-derived vasocontracting factors--arachidonic acid metabolites},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {11},
year = {2016},
keywords = {},
abstract = {Vascular endothelium releases vasocontracting and/or vasorelaxing substances. Here, we report the diversity of endothelium-derived vasocontracting factors (EDCFs), arachidonic acid metabolites, and discuss the pathophysiological significance. In the canine basilar artery and the rabbit intrapulmonary artery, acetylcholine-induced contractions (ACh-induced EDC) are due to endothelial thromboxane A2 (TXA2) (TXA2-type). The ACh-induced EDC in the rabbit coronary artery is due to endothelial leukotrienes (LTs) (LTs-type). In addition, in the rat coronary artery, nicotine and noradrenaline (NAd)-induced EDCs are due to endothelial COX-metabolites (COX metabolite-type). These arachidonic acid metabolites derived from endothelium (activation by vasoactive substances including ACh, NAd and nicotine) cause a contraction of vascular smooth muscle cells and may disturb the local circulation. These EDCFs (TXA2, LTs and COX-metabolites) may be involved in the pathophysiology of cardiovascular immuno-inflammatory diseases.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8998}
}