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Effects of O-(4-ethoxyl-butyl)-berbamine on isolated frog hearts

   
@article{APS8976,
	author = {Guang-Hua Zheng and Zhong-Lun Chen and Jia-Hua Jiang},
	title = {Effects of O-(4-ethoxyl-butyl)-berbamine on isolated frog hearts},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effects of O-(4-ethoxyl-butyl)-berbamine (EBB) on isolated frog heart. METHODS: The isolated frog hearts were prepared with Straub's method; heart contractions were recorded using LMS-2A recorder by tonotransducer. RESULTS: EBB 1-100 mumol.L-1 caused concentration-dependent increase in systolic and diastolic activities, but did not alter the heart rate. EBB 250-500 mumol.L-1 slowed the heart beats and caused ventricular asystole. Cimetidine 10 mumol.L-1 or prazosin 100 mumol.L-1 did not inhibit the positive inotropic action of EBB. Whereas verapamil 0.01 mumol.L-1 antagonized the positive inotropic action of EBB. EBB enhanced positive inotropic action of CaCl2. The action of EBB was slower but longer than caffeine or isoproterenol. At room temperature (21.0 +/- 0.5) degree C, however, the onset of oubain was slower, but the duration of its peak action was longer, than EBB. CONCLUSION: The positive inotropic action of EBB was, at least partially, via promoting the inward current of [Ca2+]o, rather than increasing the intracellular Ca2+ release.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8976}
}