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Intracerebroventricularly injected L-arginine-induced vasopressin release is mediated by cGMP in rats.

   
@article{APS8962,
	author = {Lu-Xiang Cao and E Shen},
	title = {Intracerebroventricularly injected L-arginine-induced vasopressin release is mediated by cGMP in rats.},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the possible role of cGMP in the effect of L-arginine-induced arginine-vasopressin (AVP) release. METHODS: In anesthetized rats, saline, L-arginine, 8-Br-cGMP, L-arginine + methylene blue (an inhibitor of guanylyl cyclase) were injected intracerebroventricularly (icv) and the plasma vasopressin level was detected with radioimmunoassay. RESULTS: Both 8-Br-cGMP 2.53 g.L-1 and L-arginine 100 g.L-1 increased plasma AVP level [from (2.6 +/- 0.3) to (6.6 +/- 0.4) ng.L-1, and from (3.2 +/- 0.5) to (5.8 +/- 1.4) ng.L-1, respectively; P < 0.01] 5 min after the icv injection; methylene blue (3.74 g.L-1) + L-arginine (100 g.L-1) did not change plasma AVP level. CONCLUSION: cGMP was a mediator of the effect of L-arginine-induced AVP release.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8962}
}