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Effect of procainamide on ultrastructure of blood platelet in rabbits

   
@article{APS8936,
	author = {Lian-Pu Liu and Chun-Wen Shan and Xi-Hong Liu and Huan-Cai Xiao and Shu-Qin Yang},
	title = {Effect of procainamide on ultrastructure of blood platelet in rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of procainamide (PA) on the ultrastructure of blood platelets. METHODS: Arachidonic acid was added to PA-treated platelet-rich plasma to induce platelet aggregation. The 50-nm sections were examined with a transmission electron microscope. 
RESULTS: PA 8.5-136 mumol.L-1 markedly inhibited changes of pseudopods, alpha-granules, dense granules, glycogens, open canalicular system, and dense tubular system. 
CONCLUSION: PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8936}
}