How to cite item

Effect of mitoxantrone on DNA polymerase of Ehrlich ascites carcinoma cells

   
@article{APS8931,
	author = {Li-Jian Xian and Han-Xi Li and Zong-Chao Liu and Qi-Chao Pan},
	title = {Effect of mitoxantrone on DNA polymerase of Ehrlich ascites carcinoma cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of mitoxantrone (Mit) on DNA polymerases of tumor cells. METHODS: DNA polymerases of Ehrlich ascites carcinoma cells were isolated by phosphocellulose column chromatography. The effects of Mit on DNA polymerase alpha, beta, and gamma were detected by method of K Ono. 
RESULTS: Mit inhibited DNA polymerase alpha, beta, and gamma, IC50 values were 11.9, 6.5, and 11.9 mumol.L-1, and Ki 1.86, 2.22, and 2.05 mumol.L-1, respectively. The inhibitory mode of Mit on DNA polymerase alpha, beta, and gamma was competitive. 
CONCLUSION: Mit is a strong inhibitor on DNA polymerase alpha, beta, and gamma. The inhibitory mode was competition with respect to template DNA.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8931}
}