@article{APS8926,
author = {Xiao-Feng Zhu and Xi-Long Zhao and Chang-Geng Zhu and Jin-Xi Wang},
title = {Effect of Coriaria lactone on cytosolic free calcium of cultured neurons from rat cerebral cortex},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of Coriaria lactone (CL) on cytosolic free calcium ([Ca2+]i) of cultured neurons from cerebral cortex.
METHODS: Primary neuron culture (14d) and AR-CM-MIC cation measurement system were used, the [Ca2+]i were measured. CL effect was observed by loading egtazic acid.
RESULTS: The [Ca2+]i of cultured neurons (99.4-103.4) nmol.L-1 was elevated concentration-dependently by CL (25-500) mumol.L-1 (P < 0.01). This effect disappeared after loading egtazic acid 5 mmol.L-1, but reappeared after adding CaCl2 to 1 mmol.L-1.
CONCLUSION: The [Ca2+]i of cultured neurons was elevated by CL, depending on extracellular Ca2+.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8926}
}