@article{APS8891,
author = {Bao-Feng Yang and Da-Li Luo and Li-Hua Bao and Yong-Chun Zhang and Hui-Zhen Wang},
title = {Artemisinin blocks activating and slowly activating K+ current in guinea pig ventricular myocytes},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of artemisinin (Art) on outward rectifier potassium current in ventricular myocytes.
METHODS: In isolated guinea pig ventricular myocytes, the effects of Art on the two components of delayed outward rectifier K+ current (IK), the rapidly activating inward K+ current (IKr), and the slowly rectifying outward K+ current (IKs) were observed by the whole cell patch-clamp technique.
RESULTS: Art decreased IK in a concentration-dependent manner. The IKstep and IKtail were reduced from 387 +/- 46 pA to 240 +/- 48 pA and from 299 +/- 30 pA to 130 +/- 38 pA, respectively at holding potential of +40 mV by Art 50 mumol.L-1. The envelope of tail analysis suggested that both IKr and IKs were inhibited. CONCLUSION: Art blocked the two components of delayed outward rectifier K+ current (IKr and IKs) in guinea pig ventricular cells.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8891}
}