@article{APS8888,
author = {Guang-Qin Zhang and Xue-Mei Hao and De-Zai Dai and Yu Fu and Pei-Ai Zhou and Cai-Hong Wu},
title = {Puerarin blocks Na+ current in rat ventricular myocytes},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {12},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of puerarin (Pue) on Na+ channel in rat ventricular myocytes.
METHODS: Whole-cell patch-clamp technique was applied on isolated cardiomyocytes from rats.
RESULTS: Pue inhibited cardiac INa in a positive rate-dependent and dose-dependent manner, with an IC(50) of 349 micromol/L. The kinetics of blockage of cardiac sodium channel by Pue resembled the ClassIa/Ic of antiarrhythmic agents. Pue 300 micromol/L did not alter the shape of the I-V curve of INa, but markedly shifted the steady-state inactivation curve of INa towards more negative potential by 15.9 mV, and postponed the recovery of INa inactivation state from (21.9+/-1.6) ms to (54.4+/-3.4) ms (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8888}
}