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Inhibitory effect of trapidil on proliferation of cultured rat aortic smooth muscle cells induced by endothelin-1

   
@article{APS8880,
	author = {Yan Cheng and Pei-Li Gong and Fan-Dian Zeng and Xiu-Hua Liu and Jing-Yi Su and Chao-Shu Tang},
	title = {Inhibitory effect of trapidil on proliferation of cultured rat aortic smooth muscle cells induced by endothelin-1},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of trapidil (Tra) on endothelin-1-induced proliferation of cultured rat aortic vascular smooth muscle cells (VSMC). METHODS: The [3H]TdR incorporation into DNA assay, the number of VSMC, and cell cycle distribution were measured. RESULTS: Pretreated with endothelin-1 100 nmol.L-1, cell number, [3H]TdR uptake, and cell mitogenic activity increased 134% +/- 23%, 210% +/- 70%, and 86% +/- 18%, respectively. This proliferation was inhibited by Tra 5, 50, 500 mumol.L-1. The inhibitory rates were 12%-48%, 35%-54% and 15%-47%, respectively. Tra did not influence the proliferation of VSMC without endothelin-1 pretreatment. CONCLUSION: Tra antagonized the proliferation of VSMC induced by endothelin-1.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8880}
}