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Hemolytic activity of copper sulfate as influenced by epinephrine and chelating thiols

   
@article{APS8867,
	author = {Jan Aaseth and Ludmila G Korkina and Igor B Afanas'ev},
	title = {Hemolytic activity of copper sulfate as influenced by epinephrine and chelating thiols},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effects of epinephrine, homocysteine, and other complexing agents on the cytotoxicity of copper sulfate. 
METHODS: In vitro suspensions of human red cells incubated with cupric sulfate were used, and hemolysis was determined by extracellular hemoglobin. 
RESULTS: The hemolytic activity of CuSO4 (0.3 mmol.L-1) was enhanced by the presence of epinephrine and to a lesser extent by homocysteine, whereas D-penicillamine, succimer, and mercaptodextran reduced the copper-induced hemolysis. The latter 3 chelating thiols also reduced the copper-epinephrine-induced hemolysis. The plasma protein ceruloplasmin reduced markedly the copper-epinephrine-induced hemolysis, even upon concentrations < 20% of that of copper. Chromic chloride, as well, acted anti-hemolytically. 
CONCLUSION: The latter protectors may interact with the production or activity of toxic oxygen, while classical copper chelators sequester cupric ions from interaction with epinephrine or homocysteine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8867}
}