@article{APS8858,
author = {Shan Gong and Hui-Qin Zhang and Wei-Ping Yin and Qi-Zhang Yin and Yi Zhang and Zhen-Lun Gu and Zhong-Ming Qian and Pak-L Tang},
title = {Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP). METHODS: The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.
RESULTS: PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH. CONCLUSION: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8858}
}