@article{APS8840,
author = {Yang-Pei Zhang and Tao He and Jian-Min Chen and Yue-Neng Chen and Hui-Ying Xu and Guo-Cai Fan and Ying Wu},
title = {Specific curative effects of nitrosourea drugs on tumor cells with Mer--phenotype in Chinese},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {6},
year = {2016},
keywords = {},
abstract = {O6-Methylguanine DNA methyltransferase (O6-MT) activity and cellular sensitivity to nitrosourea drugs of 10 kinds of tumor cell strains derived from Chinese patients were measured by 3H radioactivity and colony-forming ability, respectively. The results in vitro showed that nimustine (Nim) 25 micrograms.ml-1 and carmustine (Car) 20 micrograms.ml-1 exhibited specific killing effects on Mer-phenotype tumor cells characterized by low O6-MT activity. In vivo both Nim and Car (25 mg.kg-1.wk-1 x 4 wk, ip) had specific curative ability to Mer- tumor cells implanted in nude mice. These findings suggested that assay of O6- MT activity in tumor biopsy could be used as a predictable guide to human tumor chemotherapy with nitrosourea compounds.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8840}
}