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Effects of aprotinin in platelet aggregation and cytosolic free calcium in swine platelets.

   
@article{APS8839,
	author = {Cai Huang and Yan-Mei Qin and Nian-Ci Liang},
	title = {Effects of aprotinin in platelet aggregation and cytosolic free calcium in swine platelets.},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Aprotinin inhibited platelet aggregation induced by thrombin (0.25 U.ml-1) with IC50 200 kIU.ml-1, and inhibited the rise of cytosolic free calcium concentration in platelets stimulated by thrombin (0.1 U.ml-1) in the absence and in the presence of Ca2+ 0.5 mmol.L-1 (IC50 117 and 50 kIU.ml-1, respectively), but had no effect on the amounts of actin and myosin heavy chain associated with cytoskeletons. These suggest that aprotinin is an anti-platelet agent and may exert its action through inhibiting the Ca2+ flux.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8839}
}