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Effects of direct lytic factors from southern Chinese cobra venom on Ca2+ movement in rabbit aorta strip

   
@article{APS8822,
	author = {Ke-Min Chen and Yong-Yuan Guan and Jia-Jun Sun},
	title = {Effects of direct lytic factors from southern Chinese cobra venom on Ca2+ movement in rabbit aorta strip},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {The purified direct lytic factors (DLF) from southern Chinese cobra (Naja naja atra) venom induced a contractile response in Ca(2+)-free Krebs' solution and a further increase in the tension following a subsequent addition of Ca2+ into bath. After depletion of intracellular Ca2+ pool by phenylephrine, DLF failed to induce any contractile response. In 45Ca2+ experiments, DLF increased both 45Ca2+ release and 45Ca2+ influx. Procaine 2 mmol.L-1 decreased the DLF induced 45Ca2+ release and 45Ca2+ influx by 67 +/- 23% and 46 +/- 32%, respectively. Nifedipine and verapamil 1 mmol.L-1 markedly inhibited the contractile response and the 45Ca2+ influx induced by DLF. These results suggest that DLF induces extracellular Ca2+ entry through voltage dependent Ca2+ channel and Ca2+ release from the intracellular Ca2+ pool which is sensitive to phenylephrine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8822}
}