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Midazolam pharmacokinetics and electroencephalographic changes in eight Chinese men

   
@article{APS8818,
	author = {Jian-Feng Lu and Mao-Fu Wu and Gang Chen and Bing-Ren Xiang and Deng-Kui An},
	title = {Midazolam pharmacokinetics and electroencephalographic changes in eight Chinese men},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Eight Chinese healthy male volunteers aged 27 +/- s 4 a were injected i.v. midazolam (Mid) 15 mg. Blood samples were collected at 0, 2, 5, 7, 10, 20, 30, 45, 60, 90, 120, 180, and 240 min. A HPLC method was established for determining the Mid concentrations in serum. The concentration-time data was fitted with biexponential curve. Pharmacokinetic parameters were: T1/2 alpha = 6.8 +2- 2.5 min, T1/2 beta = 118 +/- 27 min, Vc = 25 +/- 7 L, Cl = 393 +/- 79 ml.min-1, Vdss = 59 +/- 13 L, AUC0-infinity = 39.6 +/- 8.6 g.min.L-1. The electroencephalogram (EEG) showed a decrease in alpha activity and an increase in beta activity. The EEG pattern reverted toward baseline after 2-3 h. Pharmacokinetic and EEG findings suggest that Mid is a preferable anesthesia inducing agent.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8818}
}