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Effects of m-nifedipine on dihydropyridine binding sites in cardiac and cerebral cortex cell membranes from left ventricular hypertrophied rats

   
@article{APS8802,
	author = {Tao Xi and Man-Ren Rao},
	title = {Effects of m-nifedipine on dihydropyridine binding sites in cardiac and cerebral cortex cell membranes from left ventricular hypertrophied rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {m-Nifedipine (m-Nif 20 mg.kg-1.d-1 ig for 9 wk) decreased left ventricular weight in the renovascular hypertensive rats (P < 0.01). Though not significantly affecting the density of dihydropyridines (DHP) receptor (Bmax), m-Nif administered whether for prevention (6 wk postclipping) or for regression (9 wk postclipping), markedly decreased the total number of DHP binding sites in hypertrophied left ventricle (LV). m-Nif also reduced the dissociation constant (Kd) of DHP binding sites in the membranes of LV and cerebral cortex from cardiac hypertrophied rats (P < 0.01). These effects of m-Nif were similar to those of nifedipine (Nif) in the same dosage. The results suggest that m-Nif can prevent and regress the LV hypertrophy resulted from renovascular hypertension and reduce the total number of DHP binding sites in the membranes of LV from cardiac hypertrophied rats.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8802}
}