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Sodium channel blocking effect of scorpion venom on cultured mouse myocardiocytes

   
@article{APS8789,
	author = {Hui Qi and Guo-Gan Zhong and Long Chen and Yan Jiang and Jun-Jie Wei},
	title = {Sodium channel blocking effect of scorpion venom on cultured mouse myocardiocytes},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Myocardiocytes of mice were cultured. Action potentials were recorded with microelectrodes inside the cells. Scorpion venom from Buthus martensii Karsch 3.75 or 7.5 micrograms.ml-1 decreased the duration of action potential and all of the depolarization concerned parameters of myocardiocytes. The Vmax, TP, APA behaved apparently in a dosage-dependent way. Restoration happened after washing out. Tetrodotoxin 2.5 micrograms.ml-1 acted in a similar way. Nimodipine 3.0 micrograms.ml-1 led to a decrease in action potential duration. BaCl2 0.1 mmol.L-1 elongated the action potential duration, while decreased the parameters concerned with depolarization. These results indicate that the scorpion venom has Na+ channel blocking action.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8789}
}