@article{APS8782,
author = {Liang-Nian Song and Jin-Shan Zhang and Jian Lu},
title = {Effects of calcitriol and its analogue calcipotriol on proliferation and differentiation of human osteosarcoma cells},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {4},
year = {2016},
keywords = {},
abstract = {The effects of steroid hormone calcitriol (Cal) and its analogue calcipotriol on human osteosarcoma cell line HOS-8603 were determined. When cells grew in monolayer culture in the presence of hormones, their proliferations were inhibited both in dose- and time-dependent manners. The cells showed marked morphologic changes after a 4-d treatment to apparently less transformed fibroblast-like ones. Anchorage-independent growth studies indicated that both Cal and calcipotriol at 10 nmol.L-1 inhibited colony formation by HOS-8603 cells. As a marker enzyme of the osteoblastic phenotype, alkaline phosphatase activity was induced in response to Cal or calcipotriol 100 nmol.L-1. These results suggested that Cal and calcipotriol play an important role in regulating growth and differentiation of HOS-8603 cells.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8782}
}