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Effects of 3,6-dimethamidodibenzopyriodonium citrate on slow inward calcium current in isolated guinea pig ventricular cells

   
@article{APS8775,
	author = {Yi Cui and Yue-Hua Tan},
	title = {Effects of 3,6-dimethamidodibenzopyriodonium citrate on slow inward calcium current in isolated guinea pig ventricular cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The effects of 3,6-dimethamidodibenzopyriodonium citrate (I-65) on action potentials and slow inward calcium current (I(si)) were examined on isolated guinea pig ventricular myocardial cells. I-65 (30-100 mumol.L-1) depressed the action potential duration at 20% repolarization (APD20) and, under voltage-clamp conditions, reduced the amplitude of I(si) without changing the I-V relations. I-65 also showed use-dependent effects on I(si). These suggest that I-65 may block I(si) by acting on the inactivated state of Ca channels.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8775}
}