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Possible involvement of nitric oxide in arginine-induced analgesia

   
@article{APS8769,
	author = {Xin-Quan Ji and Xing-Zu Zhu},
	title = {Possible involvement of nitric oxide in arginine-induced analgesia},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Intracerebroventricular injection (icv) of 1-arginine (Arg, 0.5, 5.0, 50 micrograms) produced a dose-dependent prolongation in the hot-plate latency in mice. A similar result was obtained when nitroprusside (0.1, 1.0, 10 micrograms, icv) was given. Naloxone (2 mg.kg-1, ip) failed to antagonize the effects of Arg or nitroprusside. But Arg-induced antinociception was attenuated by NG-monomethyl-arginine (NMMA, 10 micrograms). 8-Bromoguanosine 3': 5' cyclic monophosphate (bromo-cGMP, 50 micrograms) also produced an antinociceptive effect. The results suggest that Arg induces an analgesia possibly via activation of nitric oxide-cGMP pathway.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8769}
}