@article{APS8767,
author = {Ben He and Da-Guang Chen},
title = {Possible involvement of atrial natriuretic factor and vasopressin in antihypertensive mechanism of clonidine in humans},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {3},
year = {2016},
keywords = {},
abstract = {To appreciate the role of some neuropeptides in the antihypertensive mechanism of clonidine, 17 patients with essential hypertension were given po clonidine 150 micrograms tid for 3 d. Plasma atrial natriuretic factor (ANF), vasopressin (Vas), and dynorphin A (Dyn A) were measured by radioimmunoassay. After the treatment, mean blood pressure (MBP), heart rate and 24 h urine norepinephrine, epinephrine were decreased, but no change was found in plasma Dyn A. The magnitudes of increased ANF and decreased Vas were correlated with the decreased MBP (r = -0.57 and 0.53, respectively, P < 0.05). These results suggest that both ANF and Vas are involved in the antihypertensive mechanism of clonidine.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8767}
}