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Purification and anticancer activity of cytotoxin-14 from venom of Naja naja atra

   
@article{APS8766,
	author = {Xiao-Yan Zhong and Guang-Feng Liu and Qing-Chuan Wang},
	title = {Purification and anticancer activity of cytotoxin-14 from venom of Naja naja atra},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Ion-chromatography of lyophilized cobra (Naja naja atra) venom on SP-Sephadex C-50 yielded 14 fractions, of which 7, 8, 9, and 10 possessed neurotoxic actions and 11, 12, 13, and 14 had cytotoxic activities. Chromatography of fraction 14 on SP-Sephadex C-25 gave cytotoxin-14. It was homogeneous on polyacrylamide gel electrophoresis with m = 7448 Da. It was a typical cytotoxin without phospholipase A2 activity and had a selective cytotoxic action on human cancer cell lines.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8766}
}