@article{APS8761,
author = {Zhen-Lun Gu and Mei-Lin Xie and Zeng-Nian Qian},
title = {Effect of quercetin on chemiluminescence of human platelets induced by arachidonic acid},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {3},
year = {2016},
keywords = {},
abstract = {Arachidonic acid (AA)-induced platelet chemiluminescence (CL) was measured with a lumiphotometer. Quercetin remarkably inhibited the CL, the IC50 of quercetin was 3 mumol.L-1. When quercetin plus aspirin, which inhibits only cyclooxygenase, was added, the inhibitory rate of platelet-CL obviously increased (P < 0.01). On the other hand, the quercetin had a scavenging effect on superoxide anion radical using alkaline sodium dithionite solution generation. The IC50 was 20.9 mumol.L-1. In addition, superoxide dismutase of 0.1 mg.ml-1 inhibited the platelet-CL by 97.8%, while mannitol, a hydroxyl radical scavenger, only by 43.3% at a concentration of 80 mg.ml-1. These results suggest that the mechanism of the inhibiting AA-induced platelet-CL by quercetin was associated with scavenging the superoxide anion radical directly and with inhibiting the cyclooxygenase.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8761}
}