@article{APS8736,
author = {Huai-Liang Wu and Guo-Ying Weng and Xue-Min Zhou and Da-Dun Cheng},
title = {Distribution of harringtonine positively and negatively charged liposome in rat tissues},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {2},
year = {2016},
keywords = {},
abstract = {Distribution of harringtonine positively and negatively charged liposome (HL(+), HL(-)) and harringtonine free drug (FH) in rat tissues were measured by HPLC. Their LD50 in mice were compared. The results showed that distribution of HL(+), HL(-), In vivo may be changed, that the amount of HL(+), HL(-) was increased in the liver, lung, and spleen and in these tissues it was 2-30-fold higher than that of HF after iv 2 h. HL(+), HL(-) may aid to permeate through the blood-brain, blood-testicle barrier, and to reduce acute lethal toxicity. Areas under the time curve of HL(+), HL(-) in brain and testis within 2 h were 2-4.5 times as much as those of HF. There were significant differences in the fate between negatively and positively charged liposomes in vivo.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8736}
}