@article{APS8728,
author = {Shu-Hua Xiao and Jian-Jun Feng and Hui-Fang Guo and Pei-Ying Jiao and Min-Yi Yao and Wei Jiao},
title = {Effects of mebendazole, albendazole, and praziquantel on succinate dehydrogenase, fumarate reductase, and malate dehydrogenase in Echinococcus granulosus cysts harbored in mice},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {2},
year = {2016},
keywords = {},
abstract = {Echinococcus granulosus cyst wall possess high biochemical activities of malate dehydrogenase (MD) and fumarate reductase (FR), but low activity of succinate dehydrogenase (SD), suggesting that the cyst wall may utilize a partial reverse tricarboxylic acid cycle. When infected mice were given intragastrically with mebendazole, 25-50 mg.kg-1.d-1, albendazole 300 mg.kg-1.d-1 or praziquantel 500 mg.kg-1.d-1 for 7-14 d, no apparent effects on SD and FR activities of the cyst wall were found, while the MD activity was suppressed by all the 3 drugs, the inhibition rates being 34.6-61.6%, 59.8%, and 50.6%, respectively. The results suggested that MD may not be an important target for the antihydatidosis drugs.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8728}
}