@article{APS8722,
author = {Jun Zhou and Bo Xuan and De-Xin Li},
title = {Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats},
journal = {Acta Pharmacologica Sinica},
volume = {14},
number = {2},
year = {2016},
keywords = {},
abstract = {The effects of tetrahydroberberine (THB) on ischemic and reperfused myocardium were studied in comparison with verapamil (Ver). In anesthetized rats, THB and its analogues, l-THP and l-SPD, reduced the infarct size after 4 h of left anterior descending coronary artery (LAD) ligation. In Langendorff hearts, in common with Ver, THB 1 and 10 mumol.L-1 markedly decreased the incidences of ventricular tachycardia (VT) and ventricular fibrillation (VF) in the reperfusion period. The malondialdehyde content and xanthine oxidase activity were also decreased in global ischemic-reperfused hearts pretreated with THB (P < 0.01, or P < 0.05). It suggested that THB could protect the myocardium from ischemic and reperfusion injury.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8722}
}