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Phencyclidine receptors in porcine coronary artery

   
@article{APS8709,
	author = {Gang-Gang Shi and Shao-Fen Xu},
	title = {Phencyclidine receptors in porcine coronary artery},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {By using radioligand assay, there was a phencyclidine (Phe) binding site in porcine coronary artery. This binding was specific, reversible, saturable, and stereoselective. The Scatchard analysis showed that the binding site was a single class, with dissociation constant (Kd) and maximum binding (Bmax) of 27.7 +/- 6.9 nmol.L-1 and 0.82 +/- 0.15 pmol/mg protein, respectively. The displacement experiments revealed that the [3H]Phe binding was displaced by nonradioactive Phe, TCP (Phe receptor agonists), and dextrophan (its antagonist). d-INN, a ligand of sigma receptor, had a weaker activity of displacement. These showed a dose-dependent manner. Both etorphine, an agonist of opioid receptor, and N-methyl-D-aspartic acid (NMDA), an excitatory amino acid, failed to displace the binding. These results suggest that the Phe receptors exist in the porcine coronary artery.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8709}
}