TY  - JOUR
AU  - Yang Jin-Long
AU  - Shen Zu-Ming
AU  - Lu Li-Juan
AU  - Han Jia-Xian
AU  - Xu Cheng-Hui
AU  - Li Bing-Jun
PY  - 2016
TI  - Antitumor activity of trewiasine in vitro and in vivo
JF  - Acta Pharmacologica Sinica; Vol 9, No 6 (November 1988): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Trewiasine (TWS) is a maytansinoid isolated from Trewia nudiflora seeds, a natural product from the Xishuangbanna area of China. This study demonstrates that TWS possesses a significant anti-tumor activity in vitro and in vivo. TWS 2.5-10 vg/(kg-d) x7 d ip prolonged the life-span of Ehrlich carcinoma and leukemia P388-bearing mice by 100-183% and 58-81%, respectively. The cure  rate of TWS for leukemia P388-bearing mice was 56-75%. TWS lO-8-10-2 vg/ml inhibited the growth rate of P388 cultured cells remarkably. TWS inhibited the incorporation of [3H] leucine into cell protein with T/C% by 19-24%, but it had no significant effect on the incorporation of [3H]thymidine into DNA in cell culture.
UR  - http://www.chinaphar.com/article/view/8685