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Antitumor activity of trewiasine in vitro and in vivo

   
@article{APS8685,
	author = {Jin-Long Yang and Zu-Ming Shen and Li-Juan Lu and Jia-Xian Han and Cheng-Hui Xu and Bing-Jun Li},
	title = {Antitumor activity of trewiasine in vitro and in vivo},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Trewiasine (TWS) is a maytansinoid isolated from Trewia nudiflora seeds, a natural product from the Xishuangbanna area of China. This study demonstrates that TWS possesses a significant anti-tumor activity in vitro and in vivo. TWS 2.5-10 vg/(kg-d) x7 d ip prolonged the life-span of Ehrlich carcinoma and leukemia P388-bearing mice by 100-183% and 58-81%, respectively. The cure  rate of TWS for leukemia P388-bearing mice was 56-75%. TWS lO-8-10-2 vg/ml inhibited the growth rate of P388 cultured cells remarkably. TWS inhibited the incorporation of [3H] leucine into cell protein with T/C% by 19-24%, but it had no significant effect on the incorporation of [3H]thymidine into DNA in cell culture.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8685}
}