@article{APS8661,
author = {She-Tuan Zhang and Xiao-Guang Li},
title = {Effects of copper chloride on the slow response action potential and oscillatory afterpotential induced by ouabaini},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {5},
year = {2016},
keywords = {},
abstract = {The effects of copper chloride (CuCl2) on slow response action potentials were studied in vitro by means of an intracellular microelectrode. CuC12 10 vmol/L reduced the amplitude, the slope of phase 4 and shortened the duration of the action potential of the rabbit sinoatrial nodes. The effects of CuCl2 100 vmol/L on the slow response action potential of guinea pig papillary muscles in KCl-rich (25 mmol/L) solution were similar to those on rabbit sinoatrial nodes. CuCl2 100 vmol/L immediately abolished the spontaneous elecrical activity and inhibited the oscillatory afterpotential of guinea pig papillary muscles which had been induced by ouabain. The results indicate that Cu2+ may suppress the slow inward current of myocardial muscles.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8661}
}