@article{APS8659,
author = {Jie-Xiong Wu and Jun-Xiu Chen},
title = {Negative chronotropic and inotropic effects of Panax notoginseng saponins},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {5},
year = {2016},
keywords = {},
abstract = {The automatic beating rate of guinea pig isolated right heart atrium was slowed down and the positive chronotropic effect of CaC12 or isoprenaline was attenuated by Ponox notoginseng saponins (PNS) 1-3 mg/ml. The force of contraction of isolated left atrium and the positive inotropic effect of CaCl2 or isoprenaline were inhibited by PNS l-6 mg/ml. The inhibitory effects were dose- and frequency-dependent. Verapamil showed a similar effects to PNS. The electrophysiological study of transmem-brane potential of isolated right papillary muscle cells revealed that both the plateau phase and duration of the action potentials were shortened by PNS l mg/ml. The results indicate that PNS is probably a calcium antagonist similar to verapamil.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8659}
}