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Selective a-adrenoceptor blocking action of melperone

   
@article{APS8634,
	author = {Zhi-Wen Jiang and Tian-Pei Liu},
	title = {Selective a-adrenoceptor blocking action of melperone},
	journal = {Acta Pharmacologica Sinica},
	volume = {9},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {High selective  a-adrenoceptor blocking action of melperone was investigated in pithed rats and isolated rat vas deferens. The selectivity ratio of al/a2 for adrenoceptor blockade of melpcrone, prazosin and yohimbine were estimated to be 1542,  3304 and 0.0225, respcctively. The value of pA2 of melperone (a2, 6.14) was lower than that of prazosin (6.25) and much lower than that of yohimbine (8.35). The results indicate that melperone  is a drug with higher aradrenoceptor blocking actlon, comparable to prazosin.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8634}
}