@article{APS8623,
author = {Bin Zhao and Xiang-Lan Zhao},
title = {Pharmacokinetic studies on 5-fluorouracil and its metabolite in rabbits by high pressure liquid chromatographyi},
journal = {Acta Pharmacologica Sinica},
volume = {9},
number = {3},
year = {2016},
keywords = {},
abstract = {A simple and specific HPLC method was developed to determine simultaneously 5-fluorouracil (5-FU) and its metabolite, 5-fluoro-2'-deoxyuridine( FUdR), in serum. 5-Bromouracil (5-BU) was added as an internal standard before extraction with 16% isopropanol in ethyl acetate. The extracts were then chromatographed using a mobile phase of water at a flow rate of 2 ml/min. Detection was made at 270 nm. The peak height ratias of 5-FU or FUdR to 5-BU were measured. After single iv doses to rabbits, pharmacokinetic parameters were compared between 6 normal white New Zealand rabbits and 6 hybrid rabbits. The A. B, Kio and Vi values were found to be significantly different between these 2 kinds of rabbits.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8623}
}